AIG‑VHT Autoimmune Gastritis QSP v1.1
Executable AI‑QSP model of autoimmune gastritis linking parietal-cell loss, acid feedback, gastrin, ECL/CgA, B12/iron and autoantibody dynamics. Added to ATLAS as aig_vht_v1_1_core_calibrated_20260707_1308Z.
Model description
The AIG‑VHT model is a Tier‑1, cross‑sectional calibrated model for steady‑state biomarker interpretation in autoimmune gastritis. It couples the autoimmune corpus module with the acid → gastrin → ECL trophic loop and intrinsic-factor gated B12/iron outputs.
- Eight dynamic states: parietal mass, ECL mass, Teff, Treg, autoantibody, gastrin, B12 and iron.
- Calibrated to digitised literature cohort means for gastrin, chromogranin A and vitamin B12.
- Profile-likelihood identifiability analysis for acid-feedback and ECL parameters.
- Includes SBML, OMEX archive, calibration targets, calibration result, profile result and manuscript files.
Use and limitations
Status: preprint / medRxiv; not peer reviewed. The calibrated biomarker arm is suitable for research interpretation and experimental-design prioritisation only.
Can do: steady-state biomarker cascade interpretation, identifiability analysis, N-of-1 overlay, experimental agenda design.
Cannot do: clinical diagnosis, treatment selection, patient-specific prognosis or validated digital-twin use. Therapy scenarios are hypothesis-generating.
Mechanistic structure
The model schematic links corpus autoimmunity to circulation readouts and therapeutic levers including low-dose IL‑2, antigen-specific tolerance, netazepide, CAAR‑T and parenteral B12/iron.
Free vs subscription boundary
ATLAS Open
- Public model card and status labels
- SBML v1.1 CORE_CALIBRATED branch
- Calibration target CSV and summary JSON
- Manuscript/preprint files and figures
ATLAS Clinical / Partner layer
- Longitudinal calibration when cohort trajectories become available
- Therapy-module recalibration and claim-control gates
- Partner-specific context-of-use and V&V report pack
- Quarterly updates with release notes and SHA-256 manifest