Research

Papers and scientific releases

Selected IQANOVA papers and platform papers supporting AI-QSP, SBML model standardisation, surrogate validation and EHMN model access.

Drug Discovery Today 2026

Validation of AI-enabled surrogate models in QSP

A practical, context-of-use-driven review for validating AI-QSP surrogates across endpoint accuracy, trajectory fidelity, uncertainty, biological plausibility, distributional agreement and computational efficiency.

DOI: 10.1016/j.drudis.2026.104729CAR-T and erythropoiesis examplesICH M15 / ASME V&V40 aligned
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Metabolites 2026 · open access

EHMN 2026 metabolic backbone

A thermodynamically refined, SBML-standardised human metabolic network for genome-scale analysis and QSP integration, designed for reproducibility, interoperability and multi-layer modelling.

Metabolites 16, 236Published 31 March 2026SBML L3V2 / FBC2
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Metabolites 2026 · open access

EHMN2026T diagnostic-metabolite interpretation

A license-aware AI-QSP integration framework linking EHMN2026 with TRANSFAC, TRANSPATH and HumanPSD for diagnostic-metabolite interpretation and controlled model-building workflows.

Metabolites 16, 469Published 4 July 2026Licensed knowledge layers
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How the papers connect

EHMN 2026

Provides the thermodynamically refined, SBML-standardised metabolic backbone for genome-scale and QSP integration.

EHMN2026T

Adds a license-aware diagnostic-metabolite interpretation layer linking metabolic genes to regulatory, signalling and translational context.

AI-QSP surrogate validation

Defines validation expectations for accelerated surrogates used in dynamic, decision-relevant QSP workflows.

ATLAS deployment

Turns models and workflows into versioned website assets, reports, CSV/JSON outputs and controlled access layers.